DEFICIENT KETOGENESIS IN NEONATAL HYPOGLYCEMIA

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Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice.

Peroxisome proliferator activated receptor-α (PPARα) is a master transcriptional regulator of hepatic metabolism and mediates the adaptive response to fasting. Here, we demonstrate the roles for PPARα in hepatic metabolic adaptations to birth. Like fasting, nutrient supply is abruptly altered at birth when a transplacental source of carbohydrates is replaced by a high-fat, low-carbohydrate milk...

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Neonatal Hypoglycemia.

Lower blood glucose values are common in the healthy neonate immediately after birth as compared to older infants, children, and adults. These transiently lower glucose values improve and reach normal ranges within hours after birth. Such transitional hypoglycemia is common in the healthy newborn. A minority of neonates experience a more prolonged and severe hypoglycemia, usually associated wit...

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Neonatal Hypoglycemia

A term male infant was born after an uneventful pregnancy to a 28-year-old gravida I woman who had no evidence of hyperglycemia and no chronic diseases. The infant had Apgar scores of 7 and 9 at 1 and 5 minutes, respectively. His growth parameters were in the normal range, with weight at the 60th percentile, head circumference at the 50th percentile, and length at the 50th percentile. The baby ...

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Neonatal hypoglycemia.

PURPOSE OF REVIEW Hypoglycemia in the newborn may be associated with both acute decompensation and long-term neuronal loss. Studies of the cause of hypoglycemic brain damage and the relationship of hypoglycemia to disorders associated with hyperinsulinism have aided in our understanding of this common clinical finding. RECENT FINDINGS A recent consensus workshop concluded that there has been ...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1977

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-197704000-00912